RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
Gas5
RNA ID
RNA Type
lncrna
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
PCR; immunofluorescence etc.
Target
PTEN-MMP2
Pathway
PI3K-AKT SIGNALING PATHWAY
PubMed ID
Title
LncRNA GAS5 controls cardiac fibroblast activation and fibrosis by targeting miR-21 via PTEN/MMP-2 signaling pathway
Year
2017
Function
Gas5 plays a suppressive role in cardiac fibrosis via negative regulation of miR-21. Gas5 that upregulated or downregulated the expression of PTEN through miR-21 in cardiac fibroblasts.